Tadalafil

Not stronger — just longer lasting. While both medications treat ED effectively, tadalafil stays active in your body for up to 36 hours, compared to 4 to 5 hours with Viagra® (sildenafil). That gives you a wider window for spontaneity.

Yes. Tadalafil can interact with certain medications, including nitrates, alpha-blockers, some antibiotics, antifungals, and HIV medications. Don’t take it with drugs like nitroglycerin, doxazosin, ritonavir, ketoconazole, or “poppers.” Also avoid grapefruit or grapefruit juice for at least 72 hours — it can increase the effects of tadalafil in your body. Always talk to your doctor if you're taking other meds, especially other ED treatments.

Tadalafil is the FDA-approved generic version of brand-name Cialis®, containing the exact same active ingredient. Both are equally effective for treating erectile dysfunction and have the same safety profile. The key difference is cost — tadalafil is significantly more affordable because the patent for Cialis® expired in 2018, allowing other manufacturers to produce it. You’ll get the same results, just without the high price tag.

Tadalafil comes in different strengths, and your dose depends on whether you're taking it daily or only as needed. Daily tadalafil builds up in your system over time — for example, a 5 mg daily dose is roughly equivalent to an 8 mg as-needed dose. If you’re taking it only before sex, most men start with 10–20 mg depending on their age, health, and doctor’s guidance. Your provider will help choose the right dose for you.